Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis

• Natural products promote healthspan in rodent models of physiological ageing. Oxidative stress is a target natural products. Both brain and peripheral tissues benefit from treatment with Positive effects are observed on cognition as well physical performance. Over the last decades decrease mortality has paved way for late onset pathologies such cardiovascular, metabolic or neurodegenerative diseases. This evidence led many researchers to shift their focus researching ways extend lifespan finding increase number years spent good health; “healthspan” indeed emerging concept quest ageing without chronic disabling diseases dysfunctions. Regular consumption might improve healthspan, although mechanisms action still poorly understood. Since preclinical studies aimed assess efficacy safety these compounds growing, we performed systematic review meta-analysis mouse rat Results indicate that show robust improving resistance cognitive abilities. These promising data call further investigating underlying more depth.